What is the fuel economy of a 2025 Mercedes-Benz E450 4matic?

EPA figures for the 2025 Mercedes-Benz E450 4matic reach 25 MPG combined depending on configuration; the table on this page lists every tested engine and transmission combination.

Are there recalls on the 2025 Mercedes-Benz E450 4matic?

NHTSA lists 2 safety recall campaigns for the 2025 Mercedes-Benz E450 4matic. Check your specific vehicle by VIN on the official NHTSA site - recalls are fixed free of charge by dealers.

Mercedes-Benz · 2025

2025 Mercedes-Benz E450 4matic

Official EPA fuel economy and NHTSA recall record, best combined figure 25 MPG.

Fuel economy (EPA)

Engine	Transmission	Fuel	City	Highway	Combined	CO2 g/mi
3.0L 6-cyl	Automatic 9-spd	Premium	22	31	25	355

Safety recalls (NHTSA)

2 campaigns on record for this model year. Recall repairs are free at dealers; check your exact vehicle by VIN on nhtsa.gov/recalls.

Campaign 24V941000

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2025 E 350, E 350 4MATIC, E 450 4MATIC, and E450 4MATIC station wagon vehicles. The camber strut bracket may have been improperly welded onto the rear axle carrier, possibly resulting in separation of the bracket from the rear axle carrier.

Campaign 26V281000

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2024-2026 AMG GT, C-Class, E-Class, SL, CLE, and GLC vehicles. The infotainment control unit may reset while the vehicle is in motion and cause the instrument panel display to go blank.

Decode this car's VIN All Mercedes-Benz models

Sources: EPA fueleconomy.gov, the NHTSA recalls, complaints and 5-Star Safety Ratings databases (all US public data), refreshed monthly. Recall texts are quoted from the official record. Details on About & Data Sources.