Mercedes-Benz ยท 2021

2021 Mercedes-Benz S500 4matic

Official EPA fuel economy and NHTSA recall record, best combined figure 24 MPG.

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Fuel economy (EPA)

EngineTransmissionFuelCityHighwayCombinedCO2 g/mi
3.0L 6-cyl Automatic 9-spd Premium 20 29 24 372

Safety recalls (NHTSA)

7 campaigns on record for this model year. Recall repairs are free at dealers; check your exact vehicle by VIN on nhtsa.gov/recalls.

Campaign 21V789000

Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2021 S500, S580, and Maybach S580 vehicles. The air bag control unit software may deactivate the occupant recognition control unit, resulting in a deactivated front passenger air bag.

Campaign 22V493000

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2022 AMG EQS53, EQS580, EQS450, 2021 S500, S580, and Maybach S580 vehicles. The rearview camera may not display the rearview image due to a software error in the MBUX multimedia system. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 111, "Rear Visibility."

Campaign 22V167000

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2022 EQS 450, EQS 580, and 2021 S500 and S580 vehicles. A software error may disable the rear turn signals, hazard lights, and reverse lights.

Campaign 22V214000

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 S580 4Matic and S500 4Matic vehicles. The electrical connector to the steering column module may not be secured properly, which can disable gear shifts and/or safety features including the electronic stability program, the driver's air bag, and turn signal indicators.

Campaign 22V365000

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. An error in the communication module's SIM card software can cause a mobile network connecti

Campaign 24V807000

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 Maybach S 580 4MATIC, S 500 4MATIC, and S 580 4MATIC vehicles. The emergency call system may fail to place an automatic or manual call and may not provide the vehicle location as intended.

Campaign 25V116000

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 S 500, Maybach S 580 4MATIC, 2021-2023 S 580 4MATIC, 2022 S 680 4MATIC, and 2023 S 580e 4MATIC vehicles. The front brake hoses may rupture and leak brake fluid.

Owner complaints (NHTSA)

1 complaints filed by owners for this model year. Complaints are owner reports, not confirmed defects - browse them in full on nhtsa.gov.

Engine And Engine Cooling 1

Frequently Asked Questions

What is the fuel economy of a 2021 Mercedes-Benz S500 4matic?

EPA figures for the 2021 Mercedes-Benz S500 4matic reach 24 MPG combined depending on configuration; the table on this page lists every tested engine and transmission combination.

Are there recalls on the 2021 Mercedes-Benz S500 4matic?

NHTSA lists 7 safety recall campaigns for the 2021 Mercedes-Benz S500 4matic. Check your specific vehicle by VIN on the official NHTSA site, recalls are fixed free of charge by dealers.

What are common problems with the 2021 Mercedes-Benz S500 4matic?

Owners have filed 1 complaints with NHTSA for the 2021 Mercedes-Benz S500 4matic, most often about: Engine And Engine Cooling. Complaint counts reflect what owners report, not confirmed defects.

Sources: EPA fueleconomy.gov, the NHTSA recalls, complaints and 5-Star Safety Ratings databases (all US public data), refreshed monthly. Recall texts are quoted from the official record. Details on About & Data Sources.